Avoid Xylitol Sweetener, Deadly to Dogs

By Jane Barthelemy. Is Xylitol a healthy sweetener? Touted as a safe sugar substitute in diabetic snacks, chewing gums, candies, toothpaste, and your grocery aisle, yet Xylitol can cause liver failure in dogs, gastric distress in humans, and is surprisingly high in calories. Are we getting incomplete information? What’s the whole story?

Xylitol Risks:

  1. Xylitol is deadly to dogs, causing liver failure. Never give leftovers or xylitol snacks to your dog. Signs of xylitol poisoning include weakness, lethargy, depression, walking drunk, acute collapse, vomiting, trembling or seizures, high heart rate, yellow gums, black-tarry stool, diarrhea, or death. Click here for emergency procedures if your dog ingests it.
  2. Xylitol is high in calories and carbs. With 2/3 of the calories and carbs of table sugar, it is not a low-calorie sweetener. It won’t help you cut calories or lose weight. There are better solutions – see the sweetener comparison chart below.
  3. Xylitol gives you a glycemic rush. With a glycemic index of 7 – 13 compared to table sugar’s GI of 64, it is not a diabetic-friendly sweetener. You will definitely feel a slight blood sugar spike from Xylitol, and this certainly won’t help you break the sugar habit.
  4. Xylitol Causes Gastric Distress – Consuming more than 30 – 60 grams (2 1/2 – 5 tablespoons) can cause intestinal bloating, gas and diarrhea in humans. I can personally attest to this. I get painful gas and diarrhea on just a tiny bit. However some people are not affected.
  5. Xylitol is usually made from GMO corn. Corn stalks are the cheapest source of xylitol, but extremely damaging to the environment. However since GMO products aren’t labeled, it may be hard to tell if your xylitol is GMO-based.
  6. Xylitol from birch is not environmentally friendly. Stripping the bark kills the birch tree, which takes about 15 years to grow to harvest size.


Xylitol Advantages:

  1. Improved dental health. Xylitol doesn’t cause tooth cavities, as it cannot be metabolized by plaque bacteria.
  2. Convenient. Xylitol can be easily measured cup for cup like table sugar.
  3. Lower blood sugar levels. Xylitol does not spike blood sugar as much as table sugar.
  4. Lower in calories. Xylitol is 34% lower in calories than table sugar.

What is Xylitol?
Xylitol is a granulated sweetener that tastes almost exactly like sugar, made from fermented plant pulp. Originally made from birch bark, now it is usually made from GMO corn stalks, cobs, and husks. Xylitol can be extracted from raspberries, oats, mushrooms, corn, sugar cane fiber, and birch bark. Xylitol has a cooling taste, which makes it a popular sweetener for chewing gum, mints, and toothpaste.

Xylitol is a 5-carbon sugar alcohol that occurs in nature and can be fermented using single-celled yeasts of specific genus such as Candida, Pichia, Pachysolen or Debaryomycesmicrobe. Most of the world’s Xylitol is produced in China from GMO corn. Danisco, a Danish food industry owned by the DuPont chemical company, is also a producer. Xylitol has been approved in the EU as food additive #E967. Production methods and qualities vary widely. Xylitol prices vary widely too – from $5 to $13 per pound.

Neither GMO corn or Birch Bark Environmentally Sustainable
There are many myths about the superiority of birch vs. GMO corn xylitol, but there appears to be no molecular difference between these two end products. However the cost and environmental impact of the two are quite different. GMO corn xylitol is cheaper to produce, and birch is far more expensive. Chinese corn xylitol is even cheaper because of lower labor rates. These cost factors are reflected in price variations for different types of xylitol. Which type is most sustainable? Well, consuming GMO products is harmful for all living things. Birch trees can be grown sustainably, however it’s difficult to know your hardwood source. So neither GMO corn nor birch are perfect solutions. My favorite choice is xylitol made from organic or non-gmo corn, as it is renewable, less expensive than wood, and causes less environmental damage.

How is Xylitol Made?
There are several ways to make Xylitol. Originally produced from birch bark, one common method is to extract it from corn husks, cobs, or stalks in 5 steps:

  1. Industrial production starts by extracting xylan, a hemicellulose (plant fiber), from corn husks, cobs, or stalks.
  2. It is then acid-hydrolyzed into xylose and catalytically hydrogenated at high temperatures using a catalyst called Raney nickel (nickel-aluminium alloy). The result is xylose and acetic acid.
  3. By heating and evaporating, the residues of acetic acid, hydrolyzing acid, and nickel-aluminum are removed.
  4. It is then mixed with ethanol to stabilize it into a crystalline granulated form.
  5. The crystals are centrifuged to separate from ethanol. The result is Xylitol.

There are many ways to produce xylitol. Another method ferments dilute xylose from plant fibers, which converts the free xylose to xylitol, and most of the free hexoses to ethanol. The fermented result is then filtered or centrifuged to remove the yeast. The ethanol is removed by evaporation or distilling. The mixture is then filtered using chromatographic separation into xylitol, which can be crystallized.

Xylitol is NOT Diabetic-Friendly or Low in Calories
Xylitol is advertized as a diabetic-friendly, low-calorie sweetener. With 66% the calories of table sugar, this is just a little bit lower than sugar, I would not consider it a “low-calorie sweetener”. Xylitol has a glycemic index of 7-13. While this is much lower than sugar, xylitol will give you a glycemic rush, and therefore will not help you break your sugar habit completely. For this reason xylitol is NOT the best choice for diabetics. Other possible zero-calorie, zero-glycemic natural sweeteners to consider are PureLo-Lo Han GuoJust Like Sugar-Natural Chicory root, or Swerve Sweetener-Erythritol, all of which have no carbs, no calories, and produce no glycemic or insulin response. Most so-called “healthy” sweeteners are extremely high in calories. To compute the calories accurately, you’ll need to decipher the nutrition labels. See calorie graph below. (I don’t sell sweeteners. I just research them, and I have a sensitive metabolism that doesn’t tolerate refined sugars.)

In buying Xylitol, Look for:

  • Xylitol from organic or non-GMO corn, or
  • Xylitol made from birch taken from sustainable forests

Research Sources:

American Veterinary Medical Association: Xylitol is harmful to dogs – https://www.avma.org/public/PetCare/Pages/foods-to-avoid.aspx

Xylitol toxicosis in dogs. http://www.ncbi.nlm.nih.gov/pubmed/22381181

Acute hepatic failure and coagulopathy associated with xylitol ingestion in eight dogs.  http://www.ncbi.nlm.nih.gov/pubmed/17014359

Experimental acute toxicity of xylitol in dogs: http://www.ncbi.nlm.nih.gov/pubmed/19754913

Xylitol poisoning in Dogs: http://www.pet-health-care-gazette.com/2009/04/12/xylitol-poisoning-in-dogs/

Metabolic Engineering of Saccharomyces cerevisiae for Conversion of d-Glucose to Xylitol and Other Five-Carbon Sugars and Sugar Alcohols , by Mervi H. Toivari http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042063/

Official Xylitol site: http://xylitol.org/about-xylitol/corn-xylitol-vs-birch-xylitol

GMO-Compass.org – European-based GMO information site: http://www.gmo-compass.org/eng/database/e-numbers/293.xylitol.html

EU food industry website: http://www.food-info.net/uk/e/e967.htm

Current trends in biotechnological production of xylitol and future prospects: http://www.academia.edu/202140/Current_trends_in_biotechnological_production_of_xylitol_and_future_prospects

D-Xylitol: Fermentative Production, Application and Commercialization by Silvio Silvério da Silva, Anuj Kumar Chandel http://books.google.com/books

US Patent: Acid hydrolysis of a pentosan raw material US 4008285 A: http://www.google.com/patents/US4008285

US Patent: Methods for production of xylitol in microorganisms, using inexpensive substrates such as hemicellulose hydrolysates. Birch tree hydrolysate is obtained as a byproduct of the paper and pulping industry, using high pressure (up to 50 atm) and temperature (80-140° C.) requirements as well as the use of Raney-Nickel catalyst.  US 7960152 B2: http://www.google.com/patents/US7960152

US Patent Application by Inventors: Xiyun Zhang, Ryan C. Fong. Pentose fermentation by a recombinant microorganism. This invention provides methods and compositions suitable for the conversion of xylose to xylitol and xylulose, including nucleic acid constructs, recombinant fungal host cells, and related materials. http://www.freshpatents.com/-dt20140508ptan20140127780.php

Method for the production of xylitol, by Heikkila, Heikki (Espoo, Finland) http://www.freepatentsonline.com/5081026.html

Process for Making Xylitol, by Oscar J. Melaja, Finland, http://www.scribd.com/doc/42455133/Patent-for-Xylitol-Production

Corn vs Birch: Is one better than the other? http://www.xylitolexperts.com/

Controversies around Xylitol, by Eva Söderling: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676064/

Big Xylitol Trial Finds Scant Benefits in Adult Caries: http://www.medscape.com/viewarticle/777731

XYLITOL side effects, XYLITOL BENEFITS: http://www.zhion.com/digestion/XYLITOL.html

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